Therapeutic cosmetic products with bisphosphonates by Repharm 

What are the types and the reasons of bones diseases

There is a large number of reasons of musculoskeletal diseases. To the most common reasons belong the following:

• regular exposure;
• genetic disposition;
• rough labor;
• sedentary job;
• unbalanced dieting and bad habits;
• bones and joints injuries;
• infectious diseases;
• frequent stress and nervous exhaustion;
• overweight;
• metabolism disbalance.

The most frequent bones diseases are the following:

• salt deposition;
• osteochondrosis;
• osteoporosis;
• arthritis;
• arthrosis;
• osteoarthrosis;
• Paget disease;
• myelomatosis;
• periostitis;
• podagra.

Media publications on bisphosphonates

What are the ways to treat bones diseases

Treatment of bones and joints diseases is a long and complex process. It is not enough only to take medications for some period, but it may require the full range of measures:

• pharmacological therapy;
• exercise therapy;
• diet plan;
• mudtherapy;
• massage;
• physical therapy;
• acupuncture;
• traditional medicine;
• surgical interference.

Concerning pharmacological therapy, it also contains courses of administration of certain medicines. Among these medicines are non-steroidal anti-inflammatory agents, painkillers, drugs which regenerate the structure of bones and cartilaginous tissue and normalize metabolism.

How do cosmetic products with bisphosphonates help to treat bones diseases

Although bisphosphonates are a relatively new substance in the case of treating diseases of bones, joints and cartilaginous tissue, the medications with bisphosphonates have already proved their high efficiency. They quickly cause a long-lasting positive effect. The action of bisphosphonates is based on suppression of activity of cells, which destroy the bone tissue, and also on the metabolism regeneration on cellular level. Moreover, bisphosphonate-based agents eliminate inflammation and pain. The medications of this category proved their efficiency in treating such diseases as osteoporosis, osteochondrosis, salt deposition, and in preventing fractures as well.

Medications with bisphosphonates are produced in form of pills, injections and therapeutic creams. The last group of products is very convenient to use not only as a part of combination therapy, but also as a preventive remedy for an unlimited period. Unlike pills and injections, treatment cosmetic products with bisphosphonates do not have any contraindications.

The Repharm company offers a large series of therapeutic cosmetic products with bisphosphonates. These products are registered, passed all necessary laboratory tests and received positive feedback from massage therapists and ordinary customers. Among these products are body cream Ca-VITACTIVE, KSI cream Ca-control, AKSINIA Ca-INTERACTIVE and some others.

Lecture on the use of bisphosphonates by Repharm

Sporting creams by the Repharm company

What are the symptoms of osteoporosis?

At early stages, it is rather difficult to determine this disease. At first, it does not have any presentations, or the symptoms are similar to general malaise. Speaking about disease progression, there are distinguished the following factors:

• pain in muscles and joints, which occurs in the spine, ribs, pelvis and significantly increases in case of physical activity;
• appearance of spasms, which can especially occur at night;
• fragility and loss of hair;
• fragility and poor condition of nails;
• periodontal disease;
• frequent fractures;
• constant fatigue, quick fatigue, poor overall health;
• decrease of bone mass, which can be determined with the help of special medical testing.

What Mass Media Says About Bisphosphonates

What are the reasons of osteoporosis progression?

The greatest risk group is women after 45-50 years during menopause, when there are serious body and metabolic processes are disrupted. However, men and people of much younger age are also susceptible to the development of this disease. There are many reasons that can become risk factors:

• strict diets or fasting;
• increased physical activity;
• sedentary lifestyle;
• alcoholism and smoking (especially for men);
• diseases of adrenal glands and thyroid gland;
• anorexia, bulimia;
• lack of vitamins;
• cancer of prostate or mammary glands;
• long-term intake of drugs of corticosteroid group;
• rheumatoid arthritis

Cosmeceutical products with bisphosphonates of Repharm Company

How to treat osteoporosis

It is impossible to treat this disease using only one medical product. In such case, we are talking about a complex of products normalizing metabolism, slowing down the bone tissue destruction and promoting its recovery. Among the most effective medications that help fighting against osteoporosis are bisphosphonate-based drugs.

These elements are unique in their action and have no analogues. They not only help to stop the disease progression, but they can also normalize metabolism and restore bone tissue. Our bones are in process of constant renewal, which is based on the interaction of osteoclast and osteoblast cells: osteoclasts destroy bone, and osteoblasts renew it. In case of osteoporosis progression, the activity of the destroyers increases significantly, the regenerating cells no longer cope with their tasks. Bisphosphonates are capable of blocking the activity of osteoclasts, and creating the balance in this synthesis. In addition, bisphosphonate complexes in the basis of drugs provide a prominent analgesic effect, prevent salt accumulation, and provide antitumor effect.

Dosage forms of products with bisphosphonates

In medicine, bisphosphonate-based medications are presented in form of pills, injections, ointments and creams. Repharm Company, the manufacturer of natural medical cosmetics, provides a series of bisphosphonate-based products, which have perfectly shown themselves in complex therapy during osteoporosis treatment. In comparison with pills or injections, medical and cosmetic products of Repharm Company have no side effects and contraindications, as well as they can be taken during a long period, which is especially important in the treatment of diseases of bones and joints.

The series includes the cream for active lifestyle Ca-VITACTIVE, KSIGEL Ca-control, KSIcream Ca-control and cream AKSINIA Ca-INTERACTIVE. These products are patented; they have passes long-term clinical tests and are recommended by the leading medical centers of the country.

Sports creams with bisphosphonates of Repharm Company

How to cure the musculoskeletal system diseases

The majority of the musculoskeletal system diseases are based on the calcium metabolism disorders. Our bones and joints are in the state of constant renewal, during which osteoclast cells destroy bone tissue, while osteoblasts regenerate it. In case of normal organism functioning, this algorithm is in balance. However, under certain factors, the activity of osteoblasts decreases, thus, destruction prevails over regeneration. At the same time, calcium is leached from the bone tissue; as a result, bones become thin and fragile. In addition, calcium metabolism disorders result in accumulation of salts in the joints, which subsequently calcify and limit mobility. At the initial stages of the disease progression, you can feel discomfort, but later you will experience severe pains.

This group of diseases is very difficult to cure. Their treatment includes a large number of medication categories and methods among which non-steroidal anti-inflammatory drugs, cartilage protectors, physiotherapy procedures, therapeutic exercises, etc. The bisphosphonate complexes have proven themselves as the most effective products in the treatment and prevention of various musculoskeletal system diseases.

Publications About Bisphosphonates in the Media

Bisphosphonate products of Repharm Company

What are bisphosphonates and their functions in the treatment of bone and joint diseases?

Bisphosphonates are natural elements presented in the body of every person. They have the unique ability to block the activity of osteoclasts, which destroy bone tissue. In addition, at the cellular level, bisphosphonates regulate calcium metabolism, thereby preventing various negative phenomena. Bisphosphonate products treat a number of complex diseases of the musculoskeletal system:

• accumulation of salts;
• osteochondrosis;
• osteoporosis;
• arthritis;
• arthrosis;
• hypercalcemia;
• swelling and pain caused by trauma and mechanical injuries;
• bone metastases;
• Paget disease.

Lecture of Repharm on the use of bisphosphonates

Bisphosphonate medications of Repharm Company

Gels and ointments with bisphosphonate complexes are effective not only in the treatment, but also in the prevention of all these diseases. They also perfectly relieve pain and tension after intense physical activity, regulate metabolism, improve the functioning of joints during sports, and relieve discomfort in muscles and joints in case of sedentary lifestyle.

Repharm Company provides a series of skin care products with bisphosphonate complexes, which have proven themselves as excellent product in the treatment and prevention of many diseases of bones and joints. Their efficacy have been proven by clinical trials and practical application. The products of bisphosphonate series of Repharm Company are a cream for active lifestyle Ca-VITACTIVE, KSI gel Ca-control and KSI cream Ca-control, AKSINIA cream Ca-INTERACTIVE. In comparison with medicine remedies, bisphosphonate cosmetics have no side effects and can be used for unlimited period in case of long-term treatment.

Sports creams with bisphosphonates of Repharm Company

Why does accumulation of salts occur?

Many people mistakenly think that only the elderly people suffer from accumulation of salts. Of course, diseases of this group are more common for them than for young people, as due to the age the metabolic processes slow down and are interrupted. However, people under 30 can experience accumulation of salts. There are many causes for it:

• unhealthy diet with fatty, spicy, salty and smoked foods;
• harmful addictions – alcohol and smoking, overeating;
• systematic hypothermia;
• sedentary lifestyle, excess weight;
• intense physical activity, injuries;
• various diseases: of blood, skin, endocrine systems, kidneys;
• long-term intake of some medications.

All these causes can lead to calcium metabolic disorders, when salts start accumulating in various joints: knee, shoulder, hip, hands and elbows. The first sign of accumulation of salts is crunching and pain. After that, it is followed by inflammation, salts damage muscles and nerve endings, joint numbness appears, pain becomes constant and severe. If you do not turn to doctor in time and do not start treating disease, the joint can lose its mobility.

How to cure accumulation of salts

It should be noted that diseases related to accumulation of salts cannot be quickly cured with the help of one drug. If the process has already passed into serious stage, doctors usually recommend special diet, physiotherapy, and simultaneous use of several different groups of drugs, including anti-inflammatory products, hormonal medications, drugs regulating uric acid levels and calcium metabolic processes.

A large role of treatment process is given to topical agents, such as creams and ointments. They are also used for disease prevention, as accumulation of salts is much easier to prevent than to cure. As an additional agent to the treatment process and for the prevention of accumulation of salts, you can use special medical and cosmetic body creams, which belong to the category of calcium-regulating products.

The local manufacturer of medicinal cosmetics, the Institute of Pharmaceutical Reagents Repharm provides a series of such products. The company has developed a unique composition of elements removing salts and preventing their formation. The effectiveness of these products is confirmed by long-term clinical tests and recommendations for use by medical experts and specialists of orthopedic salons. In particular, the famous Russian network of orthopedic salons Orteka recommends cream against accumulation of salts of Repharm Company.

Calcium-regulating creams of Repharm Company

How body creams against accumulation of salts function

The main active element of Repharm Company body creams against accumulation of salts is a bisphosphonate calcium-regulating complex regulating calcium metabolic processes.

According to their composition, bisphosphonates are artificial analogue of natural elements regulating mineral metabolic processes of our body. They effectively prevent the accumulation of salts in soft tissues and joints. In addition, bisphosphonates are very effective in the treatment of various bone and joint diseases, such as osteochondrosis, osteoporosis, arthritis, arthrosis, they also relieve pain of various nature. It occurs due to the unique ability of these elements to block cells destroying bone tissue. Bisphosphonates are embedded into bone tissue and make it insensitive to the action of destroyers such as osteoclasts levigating calcium from the bones.

Learn more about the action of bisphosphonates:

• Статья к.х.н. Матковской Т.А. “Применение бисфосфонатов при заболеваниях опорно-двигательного аппарата”
• Результаты клинического применения препарата “Ксикрем” (pdf 1,0M)
• Отчет о фармакологическом эффекте 2% мази с ксидифоном “Ксикрем” при остеохондрозе (pdf 0,8M)

Who are indicated to use body creams against accumulation of salts?

It should be mentioned that accumulation of salts is usually treated under the supervision of a doctor according to his recommendations. Calcium-regulating body creams can be used as an additional agent, as they have no side effects and contraindications, and are also excellent for the prevention of diseases related to the accumulation of salts. Everyone can use body creams regardless of the causes: athletes and fitness fans, people with sedentary lifestyle or in case of intense physical activity, elderly people.

Repharm Company provides a series of body creams against accumulation of salts of various purposes that are used by different groups of customers.

• Cream for active lifestyle Ca-VITACTIVE is suitable for those who are actively involved in sports. This calcium-regulating product activates the metabolic processes of muscles and joints, relieves pain and tension occurring after long training or competitions. Many famous professional athletes already use this cream. Among them are marathon runners and ice swimmers, who set records thanks to the use of calcium-regulating products of Repharm Company. We have received excellent reviews of the Russian marathon runner, winner of 100 km trial, Igor Kurtepov and the swimmer across the English Channel and the Bering Strait, Natalya Seraya, the chairman of the ice swimming club Walruses of the Capital.
• For the elderly people, Repharm Company recommends AKSINIA Ca-INTERACTIVE body cream against accumulation of salts. The cream is specially developed for preventive anti-aging care. It regulates the metabolic processes in joints, prevents the accumulation of salts, relieves pain, eliminates edema of various nature, and helps as an additional agent in the complex treatment of accumulation of salts.
• People who are engaged in intense physical labor or have a sedentary lifestyle can use KSI cream Ca-control. KSI cream prevents accumulation of salts, relieves fatigue and muscle tension, and regulates metabolic processes in joints and muscles.

Calcium-regulating cosmetics of Repharm Company

How calcium deficiency and metabolic disorders occur

First of all, calcium metabolic disorders affect the condition of bones, muscles and joints. It results not only in the progression of such diseases as osteoporosis, osteochondrosis, arthritis, but also in spasms, muscle cramps, aches and pains in joints. In general, in case of calcium deficiency, you can experience tension, irritability. In addition, the poor condition of hair and teeth, brittle nails, skin flabbiness and dryness also indicate of the deficiency of this element.

Prevention measures of calcium deficiency should be performed in the following cases:

• sports activities;
• intense physical activity;
• sedentary lifestyle;
• stress and chronic fatigue;
• general weakness of body during transitional periods in spring and autumn;
• in case of such diseases as oncology, diseases of gastrointestinal tract, kidneys, heart, diseases of central nervous system, etc.

You can replenish calcium deficiency and regulate its metabolism not only with the help of special medications and diets, but also with skin care calcium-regulating products. It has proven itself not only in the course of treatment of various diseases of bones and joints, but also in the prevention of calcium metabolic disorders. The calcium-regulating creams and ointments consist of unique bisphosphonate complexes restoring and regulating calcium metabolic processes at the cellular level.

Repharm Company provides a series of products based on bisphosphonates, which have passed clinical tests and have proven themselves in the course of treatment and prevention of such diseases as accumulation of salts, osteochondrosis, osteoporosis, arthritis, and arthrosis. They relieve pain in muscles and joints, swelling and inflammation, as well as activate metabolic processes. People going in for sports or experiencing intense physical activity can apply Ca-VITACTIVE body cream of Repharm Company, for the prevention of bone and joint diseases and congestion neutralization in case of sedentary lifestyle you can use rosemary KSI gel Ca-control, for the treatment of diseases related to calcium metabolic disorders use KSI cream Ca-control.

Calcium cosmetic products by Repharm

Calcium influence on the skin appearance

Calcium plays very important role for the skin health. Skin elasticity, moisture capacity, resistance to the negative external influence depend on the correct calcium balance. Lack of calcium can cause some unwanted consequences:

• Skin dryness;
• Rising of sensory threshold to the negative external influence;
• Breaking the collagen and elastin fibers, loosing elasticity and wrinkles’ occurring;
• Slowing the cells restoring;
• Reducing the intracellular metabolic processes;
• Reducing the fibroblasts activity, which responsible for collagen, elastin and hyaluronic acid producing;
• Reducing of the blood vessels tone and lymph drainage activity.

Bisphosphonic cosmetic products by Repharm have shown high efficacy level in the calcium exchange regulation, treating some bones’ and joints’ issues, supporting skin health and beauty. Russian cosmetic manufacturer Repharm offers a line of calcium-regulating cosmetic products, that passed through the medical trials and proved their efficacy in practical use.

Calcium-regulating products of Repharm Company

How calcium is digested by the body

Calcium is one of the hard-to-digest elements. It is rather difficult to compensate for its deficiency or regulate metabolic processes only with the help of food. For example, the composition of some foods, such as cereals, sorrel, spinach, interfere with the calcium digestion. In addition, the excess of fluoride and magnesium significantly inhibits the calcium digestion.

The products providing our body with this important element:

• milk and dairy products of low fat content;
• dark green leafy vegetables;
• lean meat;
• fish;
• nuts;
• legumes;
• dried fruits;
• currants, strawberries, cherries.

Special vitamin complexes and dietary supplements can help to replenish the calcium deficiency. Also, the use of special skin care calcium-regulating cosmetics, which can be used both for the treatment a great number of diseases and for preventive measures, is another effective direction in regulation of metabolic processes and maintenance of calcium balance. Creams and ointments of this category regulating calcium metabolism are an effective means in the struggle against accumulation of salts, osteochondrosis, and osteoporosis, as they help to eliminate discomfort in joints and inflammation that can occur in case of intense physical and sports activity, sedentary lifestyle. In addition, calcium-regulating cosmetics gently and effectively care for the skin, preventing the progression of aging-related processes and their consequences.

Repharm Company has developed a series of natural skin care calcium-regulating products based on unique bisphosphonate complex. The creams have passed long-term clinical test, received high reviews of experts and specialists, as well as have proven themselves in practical application due to numerous positive customer reviews. The list of products of this series includes Ca-VITACTIVE cream for active life, rosemary KSI gel Ca-control and KSI cream Ca-control.

Calcium-regulating cosmetic products by Repharm

How calcium deficiency and metabolic disorders are manifested

First of all, calcium metabolic disorders affect the state of the musculoskeletal system. Such disorder can result in pain in muscles and joints, muscle spasms, cramps, increased risk of fractures, salt accumulation, such diseases as atherosclerosis, osteochondrosis, osteoporosis, arthrosis, etc.

You can replenish calcium deficiency and regulate the metabolic processes related to this minor-nutrient element with the help of well-balanced diet, calcium intake, as well as the use of special calcium-regulating products for local application: creams, gels and ointments.

Repharm Company has developed a series of medical and cosmetic products based on natural regulators of calcium metabolism – bisphosphonates. These elements regulate calcium metabolism at the cellular level, prevent the formation of crystals of calcium salt, promote the removal of salts from the body, and strengthen bone, connective and articular tissue. These products relieve muscle tension, pain, and help to restore the motor activity, increase joint mobility, regenerate nervous tissue, cure and lift the skin. The list of products of the series includes KSI gel Ca-control, cream for active lifestyle Ca-VITACTIVE, body cream KSI cream Ca-control.

Calcium regulating products by Repharm

What is the use of bisphosphonates in cosmetology

A list of bisphosphonates positive influence on skin is rather large as well. Bisphosphonates slow down the aging processes as effectively, as hyaluronic acid, peptides and other substances, which help skin to stay young and healthy. Their action is based on regulation of metabolism on cellular level, and this produces rejuvenating and therapeutic effect:

• slowdown of aging processes, prevention of wrinkles formation and aging changes;
• fight with excessive fat tissue;
• increasing of skin softness, elasticity and firmness;
• regeneration of damaged cells;
• activation of metabolism in the deep skin layers;
• moisturizing effect.

Among the Repharm company products there is a series of cosmetic and therapeutic creams with bisphosphonate complex as a main ingredient. This series of products contains the following facial and eye creams: Repharm #, Repharm # 3, Repharm #4, anti-wrinkle cream Aksinia Ca-INTERACTIVE, Rose Oil Cleansing Milk and others. Besides that, this category of cosmetics includes body care creams and therapeutic products focused on treating various bones and joints disorders: body cream Aksinia Ca-INTERACTIVE against salt deposition, KSI cream Ca-control, KSI gel Rosemary Ca-control, etc. All these products are registered and clinically tested.

Calcium regulating products by Repharm

Medical cosmetic products by Repharm

How do medical cosmetic products differ from regular cosmetic products

The cosmetic products of this category have several differential characteristics, except for content of certain treating ingredients:

• they are being sold only in pharmacies;
• their expiration date is rather small in comparison with regular cosmetic products. This is caused by the fact, that these products have no chemical cosmetic preservatives and have mainly natural ingredients in their formula;
• they have patent. There are the same requirements applied to medical cosmetic products as to medicines, that is why they undergo serious clinical trials before coming in retail;
• a large majority of these cosmetic products are hypoallergic, as they have no colorants, artificial flavors, perfumes and other aggressive ingredients;
• medical cosmetic products are used in cycles but not consistently, as medicines;
• they have best value for money, since producers of medical cosmetics invest money in their product efficiency but not in brand and package design;
• they are presented only by originals without any counterfeiting. This is caused by the fact, that these products are unknown for large audience, and there is no reason to falsify them. Besides that, as they are being sold only in pharmacies, producer’s sole agency in the certain country pose a problem for counterfeiting of this group of cosmetic products;
• the main purpose of medical cosmetic products is not to conceal an imperfection, but to remove it totally.

Among medical cosmetic products by the Repharm company there is a unique series of patented products based on natural regulator of mineral metabolism — bisphosphonate complex. These are body creams Ca-VITACTIVE, «Aksinia» Ca-INTERACTIVE, «Кsicream» Ca-control, rosemary «Кsigel» Ca-control. These products are intended for treatment of neuralgia, other discomforts and pain in muscles and joints, also they fight salt deposit, restore motor activity during increased exercises and after hypodynamia, are used to treat calcium metabolic imbalance.

Medical cosmetic products by Repharm