Cream for active life by Repharm

The composition of KSICREAM FORTE

The main active agents in cream KSICREAM FORTE are bisphosphonates and peptides. In medicine bisphosphonates are called substances for the bone health because of their ability to integrate into bone tissue and make them insensible to the osteoclast influence, cells which destroy bone tissue. Besides that, bisphosphonates support calcium balance in tissues and joints and prevent pathological conditions developing.

Peptides in KSICREAM FORTE composition encourage damaged cells regeneration, intracellular metabolism and excreting toxins.

The functioning of these two components is boosted with effective phytocomponents like hot pepper, hypericum, juniper, camphor, essential oils of pepper mint, cocoa, Siberian fir and vitamin complex. This composition not only helps to reduce pain, discomfort and treatment, but beneficial to skin in slowin aging processes.

How to cure the musculoskeletal system diseases

The majority of the musculoskeletal system diseases are based on the calcium metabolism disorders. Our bones and joints are in the state of constant renewal, during which osteoclast cells destroy bone tissue, while osteoblasts regenerate it. In case of normal organism functioning, this algorithm is in balance. However, under certain factors, the activity of osteoblasts decreases, thus, destruction prevails over regeneration. At the same time, calcium is leached from the bone tissue; as a result, bones become thin and fragile. In addition, calcium metabolism disorders result in accumulation of salts in the joints, which subsequently calcify and limit mobility. At the initial stages of the disease progression, you can feel discomfort, but later you will experience severe pains.

This group of diseases is very difficult to cure. Their treatment includes a large number of medication categories and methods among which non-steroidal anti-inflammatory drugs, cartilage protectors, physiotherapy procedures, therapeutic exercises, etc. The bisphosphonate complexes have proven themselves as the most effective products in the treatment and prevention of various musculoskeletal system diseases.

Publications About Bisphosphonates in the Media

Bisphosphonate products of Repharm Company

What are bisphosphonates and their functions in the treatment of bone and joint diseases?

Bisphosphonates are natural elements presented in the body of every person. They have the unique ability to block the activity of osteoclasts, which destroy bone tissue. In addition, at the cellular level, bisphosphonates regulate calcium metabolism, thereby preventing various negative phenomena. Bisphosphonate products treat a number of complex diseases of the musculoskeletal system:

• accumulation of salts;
• osteochondrosis;
• osteoporosis;
• arthritis;
• arthrosis;
• hypercalcemia;
• swelling and pain caused by trauma and mechanical injuries;
• bone metastases;
• Paget disease.

Lecture of Repharm on the use of bisphosphonates

Bisphosphonate medications of Repharm Company

Gels and ointments with bisphosphonate complexes are effective not only in the treatment, but also in the prevention of all these diseases. They also perfectly relieve pain and tension after intense physical activity, regulate metabolism, improve the functioning of joints during sports, and relieve discomfort in muscles and joints in case of sedentary lifestyle.

Repharm Company provides a series of skin care products with bisphosphonate complexes, which have proven themselves as excellent product in the treatment and prevention of many diseases of bones and joints. Their efficacy have been proven by clinical trials and practical application. The products of bisphosphonate series of Repharm Company are a cream for active lifestyle Ca-VITACTIVE, KSI gel Ca-control and KSI cream Ca-control, AKSINIA cream Ca-INTERACTIVE. In comparison with medicine remedies, bisphosphonate cosmetics have no side effects and can be used for unlimited period in case of long-term treatment.

Sports creams with bisphosphonates of Repharm Company

Why calcium metabolic disorders occur

According to expert researches, an adult required about 1 gram of calcium every day, and after 40, this figure starts increasing. At the same time, if by the age of 40, almost half of the world population experiences calcium deficiency and its metabolic disorders, then by the age of 60, already 90% of people face these problems.

However, age is not the only cause of such disorders. The following factors greatly influence calcium metabolic processes:

• physical activity;
• frequent stressful situations;
• sedentary lifestyle;
• unhealthy diet: intake of sweet, salty, fatty, flour products, alcohol, coffee;
• professional sports;
• long-term use of certain types of drugs: hormones, laxatives, diuretics, antiallergic drugs, drugs of tetracycline group;
• some diseases: diabetes mellitus, lack of vitamins, kidney diseases, thyroid disorders.

Consequences of calcium metabolic disorders

The majority of calcium is found in the skeleton, which entirely consists of calcium; it contains 99% of this element. Moreover, when calcium metabolic processes are interrupted, bones and joints suffer in the first instance. The reason is that in case of calcium deficiency, in order to make up its deficiency the body starts taking this element from those places where it is in excess, from the bones. Therefore, any calcium metabolic disorders can cause such diseases as osteoporosis, osteochondrosis, arthritis, and arthrosis. The first signs of calcium deficiency are joint pains, muscle tension after physical activity, prolonged motionless sitting at one place, sports activities, etc.

The accumulation of salts also occurs due to calcium metabolic disorders, but has a different nature. The accumulation of salts is the crystallization of calcium in tissues, joints and under the skin; it is difficult to treat and it greatly reduces the quality of life. The accumulation of salts can result in pain during walking and limitation of joint motion.

In addition, improper calcium metabolic processes are very harmful to our skin. In case of calcium deficiency, the skin becomes dry, irritated, and loses its natural immunity. Collagen and elastin fibers are destroyed, cell renewal slows down, and thus, wrinkles appear.

What helps to regulate calcium metabolic processes

There is a widespread belief that calcium deficiency can be replenished with the help of dairy products and special vitamin complexes. Indeed, they can help in solution of this problem, but they cannot be a panacea, as calcium is considered one of the most difficult to absorb elements. In order to regulate calcium metabolic processes, it is usually required to take a set of measures: vitamin complexes, special diet, intake of medications, and the use of special creams and ointments.

The calcium-regulating cosmetics have proven themselves as a great mean for regulation of calcium-exchange processes. It can act as a complementary tool in treatment of bone and joint diseases or can be used to prevent and maintain calcium balance.

In comparison with drugs, the great advantage of calcium-regulating creams and ointments is that they do not cause side effects and can be used continuously, in courses or whenever there is any discomfort in muscles and joints.

The local manufacturer of natural medicinal cosmetics the Institute of Pharmaceutical Reagents Repharm provides a series of calcium-regulating products. Such products of calcium-regulating series as AKSINIA cream Ca-INTERACTIVE, KSI cream Ca-control, rosemary KSI gel Ca-control, cream for active lifestyle Ca-VITACTIVE have received a great number of positive reviews. In comparison with usual cosmetics, these creams contain a complex of balanced medicinal elements that help to regulate calcium metabolic processes of skin, muscles and joints.

Such creams have been developed by Repharm Company; they are patented and have passes long clinical tests. These products belong to the category of curative cosmetics, have expert testimony, all necessary quality certificates and are sold only via the network of pharmacies.

Calcium-regulating body creams of Repharm Company

How calcium-regulating creams function

The calcium-regulating creams of Repharm Company consists of a bisphosphonate complex, which regulates calcium metabolic processes. Medical specialists call bisphosphonates the medications for bone and joint health, as they are able to retain calcium ions and block the cells destroying bone tissue. These elements help in treatment of such serious diseases as osteochondrosis and osteoporosis, arthritis, arthrosis, they also relieve pain, swelling, inflammation and muscle tension, which can be caused by various reasons.

In addition, bisphosphonate complex of calcium-regulating creams is very effective in removal of accumulation of salts and prevention of their accumulation.

Who is indicated for use of calcium-regulating body creams?

Calcium-regulating creams of Repharm Company can be used not only in case of problems with calcium metabolic processes. Absolutely everyone who looks after his health can use them.

During treatment of such diseases as osteoporosis, osteochondrosis, accumulation of salts, bisphosphonate creams are an effective addition to the main treatment. AKSINIA cream Ca-INTERACTIVE has received a great number of positive reviews. It is recommended not only by ordinary customers, but also by specialists of famous orthopedic salons, including the Russian orthopedic network Orteka.

Calcium-regulating creams of Repharm Company are perfect for elimination of discomfort, pain and fatigue in muscles and joints after intense physical activity or sports. The cream for active lifestyle Ca-VITACTIVE is used by many professional athletes, as it activates the metabolic processes in muscles and joints and thus, helps to improve endurance.

For the prevention of congestion in case of sedentary lifestyle, you can use KSI cream Ca-control or rosemary KSI gel Ca-control. They also help to cope with pain in case of various injuries, bruises and sprains, to relieve swelling and inflammation.

In addition, all Repharm calcium-regulating creams effectively care for the skin: preserve its youth and beauty, make it resilient and elastic.

What is the cause of cellulite

Doctors have been studying this problem for almost hundred years, but so far, they have not come to a consensus what is the cause of cellulite. Nowadays, it has become known for sure that it can appear due to metabolic disorders under the skin and in small vessels. Thus, the mechanism of cellulite formation is approximately the following. Subcutaneous fatty tissue is a cellular structure, separated by some connective septa, which allow this tissue to be evenly distributed. According to several factors, these septa become weak and cannot sustain the structure uniformity. Therefore, the fatty tissue loses its uniformity, in some places, it starts bulging, and in others, the voids appear. The alternation of such voids with tubercles of fatty tissue creates the well-known effect of ‘orange peel’.

The most common causes of cellulite are:

• Hormonal system disorders. When the level of certain hormones increases, metabolism slows down and harmful substances under our skin are accumulated faster than they are removed.
• Improper nutrition. Fatty, salty, fried, smoked, pickled food, excess salt and sugar complicate the functioning of the liver, which does not manage to cope with body cleaning.
• Insufficient intake of liquid also complicates the metabolism process and the body cannot cope with its own cleaning.
• Eating large servings at a time. In such situation, the body does not have time to activate the metabolism in order to process and remove excess fats and carbohydrates from the body, which are accumulated in problem areas.
• Excessive drinking and smoking. Alcohol promotes liquid retention in the body, while nicotine constricts blood vessels and prevents the normal oxygen flow to the cells and slows down the metabolism process.
• Sedentary lifestyle forms congestion under the skin and prevents the elimination of toxins.
• Frequent stress. During stressful situations, the brain activity is inhibited, thus, it is not managed to control the body processes, including metabolism.

The most common cellulite locations are the thighs and buttocks, but sometimes it can appear on the abdomen and arms. The body has chosen these areas not by chance, as cellulite is nothing more than fatty tissue; therefore, the cellulite areas are those areas, where most often the fat appear.

How to get rid of cellulite

It is considered that it is extremely difficult to get rid of cellulite. Sometimes people believe in it so much that they do not even try to struggle with cellulite, but vainly, as in most cases smooth and toned skin will not require great efforts. If you are engaged in getting rid of cellulite constantly and regularly, then even the simplest actions can bring you quick and stable result.

Much depends on the cellulite stage. There are four of them:

1. Cellulite is visible only when you squeeze the skin with your fingers. In such case, you will require systemic use of anti-cellulite creams and regular fitness;
2. Cellulite mons are visible and palpable. Thus, in addition to anti-cellulite creams and regular fitness you should add massage as well as try to exclude harmful food and drink more liquid;
3. Accumulation are clearly visible and prevent normal blood circulation and muscle contraction. In such case, you should add special intensive massage techniques and systemic sports;
4. Cellulite causes muscle and nerve atrophy, which can be identified by a bluish skin tone. In such situation, the problem is rather difficult and can be solved only comprehensively: anti-cellulite products, massage, sports, diet, and body wraps. At this stage, it is better to be under medical supervision.

Anti-cellulite cream is a product that is rather useful at all stages of struggling with the ‘orange peel’. In light cases, it can be enough to use only this product. In more difficult cases, when you require massage and anti-cellulite wraps, anti-cellulite cream can significantly improve the effectiveness of these procedures.

Which anti-cellulite cream is more effective

Active elements, which interact with cellulite, are caffeine, camphor, red pepper, algae, vitamin complexes, as well as essential oils: eucalyptus, lemon, sage, geranium, horse chestnut, ivy, horsetail, hawthorn, hypericum, etc.

Peptide compounds have proven their effective influence on the ‘orange peel’. Peptides are chains of amino acids, they are much smaller than proteins (which also consist of amino acids), and thus, they can easily penetrate into the deepest layers of your skin and provide a positive effect.

Nowadays, peptides are one of the most popular trends in cosmetology. These unique elements have a great variety of possibilities with positive effect on our skin, enhancing the processes inside it:

• improve metabolism;
• improve blood circulation;
• eliminate stagnant liquid;
• maintain skin tone;
• restore affected cells;
• stimulate collagen and elastin production;
• heal wounds and relieve inflammation;
• increase skin immunity.

The complex of peptides is truly irreplaceable in process of struggling with cellulite. Therefore, peptide compounds are natural product No. 1 in solving the problems of getting rid of the ‘orange peel’.

Anti-cellulite cosmetic products by Repharm

Warning!
The anti-cellulite creams contain enhanced caffeine concentration to reach anti-cellulite effect. Caffeine may form whiskers, which instantly dissolve while rubbing the cream in the skin.

Where to buy anti-cellulite cream with peptides

The Russian manufacturer of natural medical phytocosmetics, Institute of pharmaceutical reagents REPHARM, has developed a series of peptide-based anti-cellulite products. Anti-cellulite cream Peptidele has already received many positive reviews. Women who have used it personally recommend it, and this product has also received excellent reviews from massage specialists of beauty and health centers.

Anti-cellulite cream Peptidele is patented, its effectiveness is proven by clinical testing. It has all required expert testimony and quality certificates. Peptidele belongs to the category of natural medical and cosmetic products and is sold only via the pharmacy network.

The product composition is carefully selected and balanced. The peptides are complemented by the most effective anti-cellulite elements, such as caffeine, extracts of horse chestnut, brown algae, camphor, essential oils of lemon, geranium, and sage.

Peptidele can be used as a standalone anti-cellulite product or as a cream for massage. Its use significantly increases the effect of anti-cellulite wraps.

Cosmetic Products with peptides by Repharm

What are the advantages of peptide cosmetics

The main advantage of peptides themselves concerns not only their high efficiency, but also their naturalness. These elements are completely natural for our body. Their action is similar to Botox, but with the only difference, the latter has a lot of contraindications and side effects. In addition, the list of positive effects of peptides is rather wider:

• have a sound regenerating effect: they enhance the cells with essential proteins. Penetrating into the deepest layers of or skin, the amino acids of peptides have the possibility to join to the damaged cells, thus, they restore their functioning;
• form a lifting effect: peptide compounds effectively relax the facial muscles, due to which mimic wrinkles start to smooth, preventing their formation;
• heal micro cracks, wounds and skin lesions: peptide chains can intensively restore the affected skin areas. Therefore, peptide cosmetics are widely used for the care of problem skin, skin after plastic surgery or in case of impact of aggressive cosmetic procedures. The peptides are very effective in elimination of scars and stretch marks;
• deal with fat accumulation and cellulite: peptides can break down the subcutaneous fat accumulation and remove it out of the body. In addition, they clear your body from all slags, toxins, and stagnant liquid;
• strengthen the turgor and skin tone, due to which you can observe the general strengthening effect, facial contours are lifted;
• reinforce the skin immunity, which helps to neutralize the aggressive influence of the environment.

Repharm Company provides a wide range of natural cosmetics based on peptide compounds. Among these products are anti-cellulite agents, creams for problem skin, and protective cosmetics. Repharm Company develops all these products. They have passed clinical testing and proven their effectiveness in practice.

Products with peptides produced by Repharm

The calcium shortage symptoms

The symptoms of the calcium shortage are the following:

• skin dryness and flaccidness;
• nails brittleness;
• loss of hair;
• musculoskeletal disorders like bones brittleness, pain or muscular twitching;
• teeth and gingiva disorders like dental caries or parodontosis;
• vulnerability to viral diseases due to immune disorders;
• allergy;
• weakness and tiredness;
• poor blood clotting;
• central nervous system disorders etc.

Calcium cosmetics by Repharm

How to balance the calcium homeostasis in skin

As previously noted, the lack of calcium is a main reason of skin deterioration, its blood vessel thinning, loosing the elasticity, dryness, flaccidness, wrinkles appearing etc. While taking the calcium restoring therapy, which can include the calcium medicine intake and special diet, a calcium-based cosmetic products usage for the calcium balance restoring can be extremely useful.

A good example of the anti-wrinkle calcium-based cream is a face cream Aksinia by Repharm. It reduces number of wrinkles and smoothens them, prevents timeless skin fading, moisturizes, nourishes skin and removes its overtone.  The active ingredients of this cream are natural regulators of mineral homeostasis, which encourages skin regeneration and epidermal cells renovation and rejuvenates skin.

How Do Bisphosphonates Wоrk

The main pharmacological application of the bisphosphonates is preventing the bone destruction, but they also balance calcium metabolism, reduce tumor, kill pain, prevent the bones’ decalcification and the salt depositing. Due to the wide range of the possible applications, the quantity of the disorders which bisphosphonates can be helpful to cure is also very wide:

• Osteoporosis;
• Bone tumor metastasis;
• Calcium exchange disorder (hypocalcemia);
• Myeloma;
• Generative disc disease;
• Arthritis;
• Hyperparathyroid;
• Any bone tissue disorders.

The Media Publications about Bisphosphonates

Bisphosphonates are artificial alternatives of the natural bone intracellular elements, which contain two phosphonic acids in their composition. Their mode of action has not yet clearly understood, but it is based on the depression the cells that destroy bone tissue, osteoclasts, and the supporting the cells that build the bone tissue, osteoblasts. Taking part in the protein synthesis and the bones mineralization, bisphosphonates keep the bone strength and dramatically reduce chances to broke the bone due to the osteoporosis.

Bisphosphonic cosmetics Repharm

Bisphosphonic medicine for osteoporosis treatment

The modern medicine offers a number of bisphosphonic drugs for treating the osteoporosis, which can be distinguished into following groups:

• Nitrogen-free bisphosphonates (1^st generation)
• Nitrogen-containing bisphosphonates (2^nd generation)
• Bisphosphonic creams

The medicine of every group proved their highly efficacy and is widely used by doctors.

Nitrogen-free bisphosphonates

• Tiludronate improves the density of bone tissue and is used for treatment of the Paget disease and other musculoskeletal system conditions related to the bones deforming. Active component — tiludronic acid.
• Etidronate is used for treatment of the osteoporosis, Paget disease, hypocalcemia. Active component — etidronic acid.
• Clodronate slows down the bone’s tissue destruction processes by influencing on the osteoclast’s activity. Widely used in the bones’ tumor metastasis and hematologic malignancies treatment. Active component — clodronic acid.

Nitrogen-containing bisphosphonates

• Zoledronate reduces the bone tissue resorption, improves its density, reduces the fracturing chances. The most effective for treating osteoporosis and multiple myeloma. Active component — zoledronic acid.
• Ibandronate is the most effective medicine for prevention and treatment of the osteoporosis. It reduces fractures risks and removes calcium surplus while hypercalcemia treatment. Active component — ibandronic acid.
• Alendronate is a nonhormonal inhibitor of the bone tissue destruction that oppresses the resorbtion process and balances metabolic processes in the bone tissue. Active component — alendronic acid.

Bisphosphonic creams

• Aksinia body cream balances the intracellular calcium exchange by influencing on the calcium ions. It prevents the salt depositing in the muscle tissue by preventing the calcium cristallisation.
• KSICREAM contains the special composition for calcium regulation, which prevents the salt depositing and excretes salts, reduces muscle tension, kills pain and removes the inflammatory causes.
• Repharm Ca-Vitactive encourages the bones tissue regeneration, improves the bone density, balances the calcium exchange, reduces pain and inflammation.

Sporting Repharm Bisphosphonic Cosmetics

Lecture about the Bisphosphonates Use

Causes of hypocalcemia

The deficiency of macronutrient elements is formed due to the disorder of calcium metabolism, when its absorption and assimilation are retarded, or its excretion from the body intensifies. There are the following causes of hypocalcemia:

• hypoparathyroidism;
• enteropathy;
• acholia (cessation of bile flow into the small bowel);
• D-hypovitaminosis, due to the lack of sunlight or renal insufficiency;
• unbalanced diet;
• toxic shock syndrome;
• pancreas disease;
• intake of some medications (diuretics, anticonvulsants, antibiotics);
• sodium excess or lack of magnesium in blood: in the first case, when the excess sodium salts is removed, the body has to use its calcium reserves; the lack of magnesium causes the calcium accumulation in the walls of blood vessels but not in the bone tissue.

Calcium Cosmeceutical Creams by Repharm

Treatment of hypocalcemia

In general, the balanced diet can replenish the calcium deficiency. The diet should include a large amount of food containing calcium: all types of dairy products, fish, eggs, all types of greens, beans, seeds, nuts, etc. At the same time, fatty foods, carbonated drinks, chocolate, fiber, acidic food should be excluded.

However, in the majority of cases the calcium deficiency has to be replenished with the help of medications. Sometimes the use of calcium supplements can be enough. However, in case of some diseases coming with hypocalcemia, it is necessary to take a complex of drugs that not only replenishes the lack of this element in the body, but also regulates the metabolic processes.

The following medications can be used for hypocalcemia treatment:

• vitamin D3: increases the membrane permeability of the gastrointestinal tract, and, thereby, activates the calcium absorption, and also promotes the calcium absorption by bone tissues (Cholicalciferol, Aquadetrim, Videin);
• vitamin D2 (ergocalciferol);
• calcium medications. They can be represented by monomedications (calcium lactate, calcium chloride), combined medications (calcium + vitamin D or magnesium, Calcium-D3 Nycomed, Vitrum calcium, Orthocalcium); multivitamin complexes (not recommended in case of serious calcium deficiency, as they contain too little calcium: Complivit, Elevit, Kalcinova).

There should also be considered the group of medications regulating the calcium metabolism:

• analogues of parathyroid hormones: they reduce the destructive effect of osteoclasts on the bone tissue, stimulate the activity of osteoblasts, and provide an analgesic effect (Calcitonin, Miacalcic, Teriparatide);
• bisphosphonates: block the activity of osteoclasts, provide the restoration of bone tissue and regulate the metabolic processes, act as natural regulators of calcium metabolism at the cellular level, jugulate pain and inflammation in case of the musculoskeletal system diseases (etidronate, zoledronate, KSI cream).

The bisphosphonate complex in form of creams, namely KSI cream, which has no analogues, is considered unique. It has the same properties as pills or injections based on bisphosphonates, but, at the same time, it does not have any side effects and restrictions concerning the duration of use.

The reasons for calcium metabolism disorders

The reasons that can cause calcium metabolism disorders can be distinguished into several groups:

External reasons

• Diets with lack of calcium in the food, unbalanced nutrition, fasting;
• Continuous use of low calcium water;
• Expressive consumption of calcium excreting products like tea, coffee, soda water.

Internal reasons

• diseases of the gastrointestinal tract that interfere the calcium absorption like dysbiosis, candidiasis, food allergies etc;
• kidneys diseases;
• pancreas diseases, pancreatitis;
• endocrine organs diseases, various types of hypoparathyroidism;
• musculoskeletal system diseases (osteoporosis);
• excess of certain macronutrients lie lead, zinc, magnesium, iron, etc.;
• lack of vitamin

Among the individual reasons that cause a calcium deficiency, there may be a violation of its digestibility in old age, prolonged or systemic use of diuretics or laxatives, an increased need for an element under certain conditions like pregnancy, menopause, physical and mental stress etc.

The ways of calcium metabolism regulation

Slight lack of calcium in the human body can be fixed using a calcium-containing products diet and use of calcium medications like multivitamin complexes with minerals: Calcium D3 Nicomed, Calcium Lactate, Complivit, Elevit. Balancing of calcium metabolism during disorders can be more difficult. Depending on the pathology type and its degree, the following groups of agents can be involved in restoring calcium metabolism:

• parathyroid hormone preparations eliminate the leaching of calcium from the bones, normalize the calcium reabsorption in the renal tubules, thereby eliminating the calcium loss during urination;
• calcitriol, the active form of vitamin D3, increases the absorption of calcium and phosphates in the intestine and their reabsorption in the proximal renal tubules, suppresses the secretion of parathyroid hormone, regulates the process of bone mineralization. Stimulates osteoblasts, participates in cell growth and differentiation;
• calcitonin inhibits bone resorption and tubular reabsorption of calcium, thereby decreasing its concentration in the blood;
• bisphosphonates like Etidronate, Zoledronate, KSIcream, Aklasta are the complex medications that regulate intracell calcium metabolism. They prevent the bone tissue destruction, restore bone structure, excrete calcium salts and prevent their pathological depositing in tissues by blocking the activity of osteoclasts and have anesthetic, anti-inflammatory effect.

Lecture about the Bisphosphonates Use

Bisphosphonic Repharm creams

Bisprophonic application principles

The bone tissue in human body continuously regenerates by the cells of two different kinds: the osteoblast cells create new bone tissue while the osteoclast cells destroy old bone tissue. In normally functioning process the number of destroying cells is regulated by their self-annihilation, but some diseases lead to their population growth. The bisphosphonates’ use is aimed to the balancing of this homeostasis.

Bisphosphonates are the artificial alternative of the natural calcium intracellular regulation cells, it is its unique benefit. Bisphosphonates are able to hold calcium ions by the chelate structure so the connection of calcium and bisphosphonate molecules blocks calcium depositing in joints and soft tissues.

Bisphosphonic sporting Repharm creams

Bisphosphonic medical remedies

There are two kinds of bisphosphonic products, nitrogen-free and nitroge-containing ones.

Nitrogen-free bisphosphonates

• Tiludronate that improves the bone’s density and is used for treatment of the fractures and bones deforming conditions of any nature.
• Etidronate is used for treatment of the osteoporosis, hypocalcemia, oncological conditions.
• Clodronate is indicated for treatment of leukemia, lymphoma, bones metastasis, it prevents bone tissue from destroying.

Nitrogen-containing bisphosphonates

• Alendronic acid stimulates the bone tissue restoring, balances the metabolic and resorption processes. Indicated for use in cases of malignant hypercalcemia, osteitis deformans, postmenopausal osteoporosis;
• Zolendronic acid is used for the osteoclasts’ oppression;
• Clodronic acid is used for killing pain and preventing fractures;
• Ibadronic acid is used in postmenopausal period in combination with hormonal replacement therapy.

The Media Publications about Bisphosphonates

Bisphosphonic cosmeceutical products

Cosmeceutical bisphosphonic products exclude side effects occurring and indicsted for continuous use. These cosmetic products are the following:

• KSICREAM contains the bisphosphonic ingredients that reduce the calcium depositing in the soft tissues and joints and regulate the calcium exchange and reduce pain. Effective in the complex treatment of the osteoporosis, generative disc disease, artritis etc.
• Ca-Vitactive cream reduces occurring of the insoluble calcium salts depositing, encourage the tissues’ regeneration and restores the motion activity
• AKSINIA cream regulates the mineral exchange, prevents calcium salts from crystallization, improves blood microcirculation.